Epidemiological and mutational analysis of SARS-CoV-2
RECOVER-COVID19
RicErCa e sviluppO VERsus COVID19 in Campania
SARS-CoV-2 to host interaction in emerging variants
Spike mutations in emerging variants
| Variant | Lineage | Number of AA changes in Spike | Most important AA change/s in Spike | Others |
|---|---|---|---|---|
| VOC-202012/01 UK variant, British variant or Kent variant | B.1.1.7 20I/501Y.V1 |
6 | N501Y | A570D, P681H, T716I, S982A, D1118H |
| VOC-202101/02 Brazil(ian) variant | P.1 20J/501Y.V3 |
10 | K417T E484K N501Y |
Missing 7 |
| South African variant | B.1.351 20H/501Y.V2 |
8 | K417N E484K N501Y |
L18F, D80A, D215G, R246I, A701V |
| European (Spanish) variant | B.1.177 20A.EU1 |
- | A222V | D614G |
Occurrence and conservativity of Spike mutations in emerging variants
| Wildtype AA | Position | Mutated AA | #Occurrence | Variant/s | PAM 1 | Base change |
|---|---|---|---|---|---|---|
| N | 501 | Y | 31.568 | UK variant, Brazil variant, South African variant | 3 | 1 |
| E | 484 | K | 1.067 | Brazil variant, South African variant | 7 | 1 |
| K | 417 | N | 696 | South African variant | 13 | 1 |
| K | 417 | T | 36 | Brazil variant | 8 | 1 |
| A | 222 | V | 94.890 | European (Spanish) variant | 13 | 1 |
Localisation of mutations at the host interface
Recettore umano ACE2
RDB Spike
